The National Science and Maths Quiz (NSMQ) is a yearly science and mathematics-based national contest for senior high schools in Ghana. Schools try their best to excel at the contest because they know when it comes to enrollment, new students will want to know which school has won the most NSMQ.

Over the years, the quiz has become more competitive. Winners get the bragging rights and a solid foundation for students who intend to have careers in fields of science or mathematics.

1. Presbyterian Boys’ Secondary School, Legon

Presbyterian Boys' Secondary School (PRESEC) is a secondary boarding school for boys, in Legon, Accra, Ghana. It was founded in 1938, under the auspices of the Presbyterian Church of the Gold Coast.

The Basel missionary, Nicholas Timothy Clerk (1862–1961), who served as the first Synod Clerk of the Presbyterian Church of the Gold Coast from 1918 to 1932, used his tenure to advocate for the establishment of the secondary school. The school has ties with its sister schools, Aburi Girls' Senior High School and Krobo Girls Senior High School.

Years Won:

• 1995
• 2003
• 2006
• 2008
• 2009
• 2020

2. Prempeh College

Prempeh College is a public secondary boarding school for boys located in Kumasi, the capital city of the Ashanti Region, Ghana.

The school was founded in 1949 by the Asanteman traditional authority, the British Colonial Government, the Methodist Church Ghana and the Presbyterian Church of Ghana.

The School is named after the King of Ashanti, (Asantehene) Sir Osei Tutu Agyeman Prempeh II, who donated the land on which the school was built. and was modeled on Eton College in England.

Years Won:

• 2017
• 1994
• 1996
• 2015

3. St. Peter’s Secondary School, Nkwatia

St. Peter's Senior Secondary School, or PERSCO, is a Roman Catholic boys' senior high school in the Eastern Region of Ghana. The school was established in 1957 by the Divine Word Missionaries (SVD). The school is located in the town of Nkwatia Kwahu on the Kwahu Ridge.

Years Won:

• 2000
• 2005

4. Mfantsipim School, Cape Coast

Mfantsipim is an all-boys boarding secondary school in Cape Coast, Ghana, established by the Methodist Church in 1876 to foster intellectual, moral, and spiritual growth on the then Gold Coast.

Its founding name was Wesleyan High School and the first headmaster was James Picot, a French scholar, who was only 18 years old on his appointment.

Mfantsipim is nicknamed "The School" by its old boys for the fact that several other schools in Ghana such as Prempeh College were born out of it, as these schools were started with students from Mfantsipim.

Years Won:

• 1999
• 2014

5. Opoku Ware School, Kumasi

Opoku Ware School, often referred to as OWASS, is an all-boys high school in Santasi, a suburb of Kumasi, which is the capital of the Ashanti region of Ghana.

Years Won:

• 1997
• 2002

6. St. Augustine’s College, Cape Coast

St. Augustine’s College is an all-male academic institution in Cape Coast, Ghana. The school started at Amissano, a village near Elmina, in 1930. The Catholic institution was established to serve as a training college and seminary. The school was named after St. Augustine of Hippo (354 – 430 AD). The motto of the college is Omnia Vincit Labor, meaning "Perseverance conquers All". The school has a total of 11 houses.

Years Won:

• 2007
• 2019

7. Achimota School, Accra

Achimota School formerly Prince of Wales College and School, Achimota, later Achimota College, now nicknamed Motown, is a co-educational boarding school located at Achimot a in Accra, Greater Accra, Ghana.

The school was founded in 1924 by Sir Frederick Gordon Guggisberg, Dr. James Emman Kwegyir Aggrey and the Rev. Alec Garden Fraser.

It was formally opened in 1927 by Sir Frederick Guggisberg, then Governor of the British Gold Coast colony. Achimota, modelled on the British public school system, was the first mixed-gender school to be established on the Gold Coast.

Years Won:

• 1998
• 2004

8. Adisadel College

Adisadel College, popularly known as "ADISCO", is an Anglican boys' boarding school in Cape Coast, Ghana.

Adisadel College was ranked 10th out of the top 100 best high schools in Africa by Africa Almanac in 2003, based on quality of education, student engagement, strength and activities of alumni, school profile, internet and news visibility.

Years Won:

• 2016

9. Ghana Secondary Technical School, Takoradi

The Ghana Secondary Technical School is a Science and Technology oriented high school located in Takoradi on the west coast of Ghana. It is the third oldest high school in Ghana - the oldest 'non-missionary' high school.

The school was founded on the 9th of August 1909 in Accra as Accra Technical School and later changed to Government Technical School.

It moved to its current site in Takoradi in 1939. In 1953, the name was changed to Government Secondary Technical School, and in 1970, it was given its current name. Former students of the school are known as Giants, and students in the school are called Tescans.

Years Won:

• 2012

10. Pope John Secondary School, Koforidua

Pope John Senior High School and Minor Seminary (formerly St John's Seminary and College, nicknamed POJOSS), is an all-boys boarding school, located at Effiduase, Koforidua, in the Eastern Region of Ghana.

It was established in 1958 by Bishop Joseph Oliver Bowers SVD as a Catholic seminary for boys who wished to become priests.

Students are offered courses such as general arts, general science, business and visual arts to pursue and after their stay in the school, sit an external examination called the West African Senior School Certificate Examination to be placed in any of the tertiary institutions in the country.

Years Won:

• 2001

11. St. Thomas Aquinas Secondary School, Accra

St. Thomas Aquinas Senior High School is a Ghanaian public day senior high school for boys in the Osu, district of Accra in the Greater Accra Region.

The school is currently located in Cantonments, a suburb of Accra. It was established mainly to provide education for boys of the Accra Archdiocese whose parents could not afford the high cost then of sending their male children to boarding schools.

It was among five secondary schools established in 1952.

Years Won:

• 2013